Pathophysiological conditions induced by SARS-CoV-2 infection reduce ACE2 expression in the lung

Pathophysiological conditions induced by SARS-CoV-2 infection reduce ACE2 expression in the lung

SARS-CoV-2 infection causes a variety of physiological responses in the lung, and understanding how the expression of SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), and its proteolytic activator, transmembrane serine protease 2 (TMPRSS2), are affected in patients with underlying diseas...

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Bibliographic Details
Main Authors: Yoko Miura, Hirotsugu Ohkubo, Akiko Nakano, Jane E. Bourke, Satoshi Kanazawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
angiotensin converting enzyme 2 (ACE2)
idiopathic pulmonary fibrosis (IPF)
SARS-CoV-2
precision-cut lung slices (PCLS)
transmembrane protease
serine 2 (TMPRSS2)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1028613/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1028613/full

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