Spatially resolved proteomic profiling identifies tumor cell CD44 as a biomarker associated with sensitivity to PD-1 axis blockade in advanced non-small-cell lung cancer

Spatially resolved proteomic profiling identifies tumor cell CD44 as a biomarker associated with sensitivity to PD-1 axis blockade in advanced non-small-cell lung cancer

Background Most patients with advanced non-small-cell lung cancer (NSCLC) fail to derive significant benefit from programmed cell death protein-1 (PD-1) axis blockade, and new biomarkers of response are needed. In this study, we aimed to discover and validate spatially resolved protein markers assoc...

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Bibliographic Details
Main Authors: Luis M Montuenga, Roy S Herbst, Luis Paz-Ares, David L Rimm, Kurt A Schalper, Alfonso Calvo, Myrto K Moutafi, Ioannis A Vathiotis, Magdalena Molero, Sandra Martinez Morilla, Javier Baena, Niki Gavrielatou, Laura Castro-Labrador, Gorka Ruiz de Garibay, Vera Adradas, Daniel Orive, Karmele Valencia, S Ponce Aix, Jon Zugazagoitia
Format: Article
Language:English
Published: BMJ Publishing Group 2022-08-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/10/8/e004757.full

Internet

https://jitc.bmj.com/content/10/8/e004757.full

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