Extensive Structure Modification on Luteolin-Cinnamic Acid Conjugates Leading to BACE1 Inhibitors with Optimal Pharmacological Properties

Extensive Structure Modification on Luteolin-Cinnamic Acid Conjugates Leading to BACE1 Inhibitors with Optimal Pharmacological Properties

BACE1 inhibitory conjugates derived from two natural products, luteolin (<b>1</b>) and <i>p</i>-hydroxy-cinnamic acid (<b>2</b>), were subjected to systematic structure modifications, including various positions in luteolin segment for conjugation, different linke...

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Bibliographic Details
Main Authors: De-Yang Sun, Chen Cheng, Katrin Moschke, Jian Huang, Wei-Shuo Fang
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Molecules
Subjects:
beta-secretase
bace1 inhibitor
flavonoid
luteolin
cinnamic acid
Online Access:https://www.mdpi.com/1420-3049/25/1/102

Internet

https://www.mdpi.com/1420-3049/25/1/102

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