Connect-four: genomic analyses of regenerating stem cells identifies zygotic Dux factors as tumor initiators

Connect-four: genomic analyses of regenerating stem cells identifies zygotic Dux factors as tumor initiators

How, if and in which cell types embryonic gene expression programs are elicited to induce tumor formation remains poorly understood. Through genomic analyses of regenerating, p53 deficient muscle stem cells we identified various oncogenomic amplifications, including but not limited to, the zygotic t...

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Bibliographic Details
Main Authors: Jens Preussner, Jiasheng Zhong, Mario Looso, Thomas Braun, Johnny Kim
Format: Article
Language:English
Published: Taylor & Francis Group 2019-03-01
Series:Molecular & Cellular Oncology
Subjects:
cell of origin
muscle
stem cell
regeneration
genomic instability
rhabdomyosarcoma
zygotic gene activation
duxbl
duxb
dux4
tp53
met
Online Access:http://dx.doi.org/10.1080/23723556.2019.1565469

Internet

http://dx.doi.org/10.1080/23723556.2019.1565469

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