Connect-four: genomic analyses of regenerating stem cells identifies zygotic Dux factors as tumor initiators
How, if and in which cell types embryonic gene expression programs are elicited to induce tumor formation remains poorly understood. Through genomic analyses of regenerating, p53 deficient muscle stem cells we identified various oncogenomic amplifications, including but not limited to, the zygotic t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-03-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2019.1565469 |
| _version_ | 1797677146099941376 |
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| author | Jens Preussner Jiasheng Zhong Mario Looso Thomas Braun Johnny Kim |
| author_facet | Jens Preussner Jiasheng Zhong Mario Looso Thomas Braun Johnny Kim |
| author_sort | Jens Preussner |
| collection | DOAJ |
| description | How, if and in which cell types embryonic gene expression programs are elicited to induce tumor formation remains poorly understood. Through genomic analyses of regenerating, p53 deficient muscle stem cells we identified various oncogenomic amplifications, including but not limited to, the zygotic transcription factor Duxbl/DUXB to initiate tumorigenic transformation. |
| first_indexed | 2024-03-11T22:40:41Z |
| format | Article |
| id | doaj.art-60a2f9654f304e52842207f3985ff430 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:41Z |
| publishDate | 2019-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-60a2f9654f304e52842207f3985ff4302023-09-22T09:11:00ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562019-03-016210.1080/23723556.2019.15654691565469Connect-four: genomic analyses of regenerating stem cells identifies zygotic Dux factors as tumor initiatorsJens Preussner0Jiasheng Zhong1Mario Looso2Thomas Braun3Johnny Kim4Max Planck Institute for Heart and Lung ResearchMax Planck Institute for Heart and Lung ResearchMax Planck Institute for Heart and Lung ResearchMax Planck Institute for Heart and Lung ResearchMax Planck Institute for Heart and Lung ResearchHow, if and in which cell types embryonic gene expression programs are elicited to induce tumor formation remains poorly understood. Through genomic analyses of regenerating, p53 deficient muscle stem cells we identified various oncogenomic amplifications, including but not limited to, the zygotic transcription factor Duxbl/DUXB to initiate tumorigenic transformation.http://dx.doi.org/10.1080/23723556.2019.1565469cell of originmusclestem cellregenerationgenomic instabilityrhabdomyosarcomazygotic gene activationduxblduxbdux4tp53met |
| spellingShingle | Jens Preussner Jiasheng Zhong Mario Looso Thomas Braun Johnny Kim Connect-four: genomic analyses of regenerating stem cells identifies zygotic Dux factors as tumor initiators Molecular & Cellular Oncology cell of origin muscle stem cell regeneration genomic instability rhabdomyosarcoma zygotic gene activation duxbl duxb dux4 tp53 met |
| title | Connect-four: genomic analyses of regenerating stem cells identifies zygotic Dux factors as tumor initiators |
| title_full | Connect-four: genomic analyses of regenerating stem cells identifies zygotic Dux factors as tumor initiators |
| title_fullStr | Connect-four: genomic analyses of regenerating stem cells identifies zygotic Dux factors as tumor initiators |
| title_full_unstemmed | Connect-four: genomic analyses of regenerating stem cells identifies zygotic Dux factors as tumor initiators |
| title_short | Connect-four: genomic analyses of regenerating stem cells identifies zygotic Dux factors as tumor initiators |
| title_sort | connect four genomic analyses of regenerating stem cells identifies zygotic dux factors as tumor initiators |
| topic | cell of origin muscle stem cell regeneration genomic instability rhabdomyosarcoma zygotic gene activation duxbl duxb dux4 tp53 met |
| url | http://dx.doi.org/10.1080/23723556.2019.1565469 |
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