Comparison of qPCR with ddPCR for the Quantification of JC Polyomavirus in CSF from Patients with Progressive Multifocal Leukoencephalopathy

Comparison of qPCR with ddPCR for the Quantification of JC Polyomavirus in CSF from Patients with Progressive Multifocal Leukoencephalopathy

Background: Lytic infection of oligodendrocytes by the human JC polyomavirus (JCPyV) results in the demyelinating disease called progressive multifocal leukoencephalopathy (PML). The detection of viral DNA in the cerebrospinal fluid (CSF) by PCR is an important diagnostic tool and, in conjunction wi...

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Bibliographic Details
Main Authors: Nyater Ngouth, Maria Chiara Monaco, Lorenzo Walker, Sydney Corey, Ijeoma Ikpeama, Gary Fahle, Irene Cortese, Sanchita Das, Steven Jacobson
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Viruses
Subjects:
progressive multifocal leukoencephalopathy (PML)
digital droplet PCR (ddPCR)
cerebrospinal fluid (CSF)
Online Access:https://www.mdpi.com/1999-4915/14/6/1246

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https://www.mdpi.com/1999-4915/14/6/1246

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