HES1 and HES4 have non-redundant roles downstream of Notch during early human T-cell development
In both mouse and human, Notch1 activation is the main initial driver to induce T-cell development in hematopoietic progenitor cells. The initiation of this developmental process coincides with Notch1-dependent repression of differentiation towards other hematopoietic lineages. Although well descri...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ferrata Storti Foundation
2020-01-01
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| Series: | Haematologica |
| Online Access: | https://haematologica.org/article/view/9600 |