Mutant SF3B1 promotes malignancy in PDAC

Mutant SF3B1 promotes malignancy in PDAC

The splicing factor SF3B1 is recurrently mutated in various tumors, including pancreatic ductal adenocarcinoma (PDAC). The impact of the hotspot mutation SF3B1K700E on the PDAC pathogenesis, however, remains elusive. Here, we demonstrate that Sf3b1K700E alone is insufficient to induce malignant tran...

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Bibliographic Details
Main Authors: Patrik Simmler, Eleonora I Ioannidi, Tamara Mengis, Kim Fabiano Marquart, Simran Asawa, Kjong Van-Lehmann, Andre Kahles, Tinu Thomas, Cornelia Schwerdel, Nicola Aceto, Gunnar Rätsch, Markus Stoffel, Gerald Schwank
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-10-01
Series:eLife
Subjects:
PDAC mouse model
murine PDAC organoids
TGFb-signaling
apoptosis
Online Access:https://elifesciences.org/articles/80683

Internet

https://elifesciences.org/articles/80683

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