MTHFR gene polymorphism and associated nutritional deficiency in the etiology and pathogenesis of Down syndrome

MTHFR gene polymorphism and associated nutritional deficiency in the etiology and pathogenesis of Down syndrome

Abstract Background Our aim was to evaluate the influence of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism on maternal risk for Down syndrome (DS) and observe the impact of this polymorphism on folate, homocysteine, and vitamin B12 concentrations and their association with pregnancy...

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Bibliographic Details
Main Authors: Radhika Kedar, Divya Chandel
Format: Article
Language:English
Published: SpringerOpen 2019-09-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
Down syndrome
Nondisjunction
MTHFR gene polymorphism
Online Access:http://link.springer.com/article/10.1186/s43042-019-0010-9

Internet

http://link.springer.com/article/10.1186/s43042-019-0010-9

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