Real-time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin-binding proteins

Real-time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin-binding proteins

Peptidoglycan is an essential component of the bacterial cell envelope that surrounds the cytoplasmic membrane to protect the cell from osmotic lysis. Important antibiotics such as β-lactams and glycopeptides target peptidoglycan biosynthesis. Class A penicillin-binding proteins (PBPs) are bifunctio...

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Bibliographic Details
Main Authors: Víctor M Hernández-Rocamora, Natalia Baranova, Katharina Peters, Eefjan Breukink, Martin Loose, Waldemar Vollmer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-02-01
Series:eLife
Subjects:
peptidoglycan
penicillin-binding protein
assay
bacterial cell wall
Förster Resonance Energy Transfer
Online Access:https://elifesciences.org/articles/61525

Internet

https://elifesciences.org/articles/61525

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