Deciphering the therapeutic potential of trimetazidine in rheumatoid arthritis via targeting mi-RNA128a, TLR4 signaling pathway, and adenosine-induced FADD-microvesicular shedding: In vivo and in silico study

Deciphering the therapeutic potential of trimetazidine in rheumatoid arthritis via targeting mi-RNA128a, TLR4 signaling pathway, and adenosine-induced FADD-microvesicular shedding: In vivo and in silico study

Rheumatoid arthritis (RA) is a debilitating autoimmune condition characterized by chronic synovitis, joint damage, and inflammation, leading to impaired joint functionality. Existing RA treatments, although effective to some extent, are not without side effects, prompting a search for more potent th...

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Bibliographic Details
Main Authors: Enas Omran, Abdullah R. Alzahrani, Samar F. Ezzat, Ghada Ellithy, Marwa Tarek, Eman Khairy, Mohamed M. Ghit, Ahmed Elgeushy, Tahani Mohamed Ibrahim Al-Hazani, Ibrahim Abdel Aziz Ibrahim, Alaa Hisham Falemban, Ghazi A. Bamagous, Nasser A. Elhawary, Mariusz Jaremko, Essa M. Saied, Doaa I. Mohamed
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-06-01
Series:Frontiers in Pharmacology
Subjects:
rheumatoid arthritis
mi-RNA128a
FADD-microvesicular shedding
TLR4
adenosine level
trimetazidine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1406939/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1406939/full

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