Discovery of autophagy as a universal mechanism for sex steroid synthesis in human ovary and testis

Discovery of autophagy as a universal mechanism for sex steroid synthesis in human ovary and testis

We recently discovered that lipophagy is a key mechanism to provide free cholesterol required for steroid biosynthesis in human ovary and testis. Pharmacological or genetic inhibition of autophagy by silencing of the autophagy-related (ATG) genes BECN1 (BECLIN1) and ATG5 resulted in a significant re...

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Bibliographic Details
Main Authors: Yashar Esmaeilian, Francesko Hela, Gamze Bildik, Ece İltumur, Sevgi Yusufoglu, Kayhan Yakin, Ozgur Oktem
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Autophagy Reports
Subjects:
autophagy
sex steroids
steroidogenesis
ovary
testis
human
gonadotropins
luteal phase defect
Online Access:http://dx.doi.org/10.1080/27694127.2023.2251804

Internet

http://dx.doi.org/10.1080/27694127.2023.2251804

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