Infertility in Fabry’s Disease: role of hypoxia and inflammation in determining testicular damage

Infertility in Fabry’s Disease: role of hypoxia and inflammation in determining testicular damage

IntroductionFabry’s disease (FD) is a genetic X-linked systemic and progressive rare disease characterized by the accumulation of globotriaosylceramide (GB3) into the lysosomes of many tissues. FD is due to loss-of-function mutations of α-galactosidase, a key-enzyme for lysosomal catabolism of glyco...

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Bibliographic Details
Main Authors: Luigi Sansone, Federica Barreca, Manuel Belli, Michele Aventaggiato, Andrea Russo, Giulietta A. Perrone, Matteo A. Russo, Marco Tafani, Andrea Frustaci
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Endocrinology
Subjects:
Fabry’s disease
hypoxia
inflammation
cellular and molecular rehabilitation
testicular damage
new therapeutic targets for infertility rehabilitation
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1340188/full

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https://www.frontiersin.org/articles/10.3389/fendo.2024.1340188/full

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