The trajectory of intrahelical lesion recognition and extrusion by the human 8-oxoguanine DNA glycosylase

The trajectory of intrahelical lesion recognition and extrusion by the human 8-oxoguanine DNA glycosylase

DNA glycosylases are lesion-specific enzymes that recognize specific nucleobase damages and catalyze their excision through cleavage of the glycosidic bond. Here, the authors present the crystal structures of human 8-oxoguanine (oxoG) DNA glycosylase bound to undamaged DNA and to DNA containing an i...

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Hlavní autoři: Uddhav K. Shigdel, Victor Ovchinnikov, Seung-Joo Lee, Jenny A. Shih, Martin Karplus, Kwangho Nam, Gregory L. Verdine
Médium: Článek
Jazyk:English
Vydáno: Nature Portfolio 2020-09-01
Edice:Nature Communications
On-line přístup:https://doi.org/10.1038/s41467-020-18290-2

Internet

https://doi.org/10.1038/s41467-020-18290-2

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