Mitochondrial genomic integrity and the nuclear epigenome in health and disease

Mitochondrial genomic integrity and the nuclear epigenome in health and disease

Bidirectional crosstalk between the nuclear and mitochondrial genomes is essential for proper cell functioning. Mitochondrial DNA copy number (mtDNA-CN) and heteroplasmy influence mitochondrial function, which can influence the nuclear genome and contribute to health and disease.Evidence shows that...

Full description

Bibliographic Details
Main Authors: Amanda L. Morin, Phyo W. Win, Angela Z. Lin, Christina A. Castellani
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Endocrinology
Subjects:
mitochondrial DNA
epigenome
disease
aging
metabolism
DNA methylation
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.1059085/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.1059085/full

Similar Items