Human and mouse PD-L1: similar molecular structure, but different druggability profiles

Human and mouse PD-L1: similar molecular structure, but different druggability profiles

Summary: In the development of PD-L1-blocking therapeutics, it is essential to transfer initial in vitro findings into proper in vivo animal models. Classical immunocompetent mice are attractive due to high accessibility and low experimental costs. However, it is unknown whether inter-species differ...

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Bibliographic Details
Main Authors: Katarzyna Magiera-Mularz, Justyna Kocik, Bogdan Musielak, Jacek Plewka, Dominik Sala, Monika Machula, Przemyslaw Grudnik, Malgorzata Hajduk, Marcin Czepiel, Maciej Siedlar, Tad A. Holak, Lukasz Skalniak
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:iScience
Subjects:
Therapeutics
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220311573

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http://www.sciencedirect.com/science/article/pii/S2589004220311573

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