Lactational High Fat Diet in Mice Causes Insulin Resistance and NAFLD in Male Offspring Which Is Partially Rescued by Maternal Metformin Treatment

Lactational High Fat Diet in Mice Causes Insulin Resistance and NAFLD in Male Offspring Which Is Partially Rescued by Maternal Metformin Treatment

Maternal metabolic disease and diet during pregnancy and lactation have important implications for the programming of offspring metabolic disease. In addition, high-fat diets during pregnancy and lactation can predispose the offspring to non-alcoholic fatty liver disease (NAFLD), a rising health thr...

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Bibliographic Details
Main Authors: Hannah Hafner, Molly C. Mulcahy, Zach Carlson, Phillip Hartley, Haijing Sun, Maria Westerhoff, Nathan Qi, Dave Bridges, Brigid Gregg
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Nutrition
Subjects:
lactation
dietary fat
developmental programming
NAFLD
metformin
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2021.759690/full

Internet

https://www.frontiersin.org/articles/10.3389/fnut.2021.759690/full

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