Deletion of P58IPK, the cellular inhibitor of the protein kinases PKR and PERK, causes bone changes and joint degeneration in mice.

Deletion of P58IPK, the cellular inhibitor of the protein kinases PKR and PERK, causes bone changes and joint degeneration in mice.

Objective. Protein kinase-like endoplasmic reticulum kinase (PERK) and protein kinase R (PKR) are implicated in endoplasmic reticulum stress-induced arthritis and pro-inflammatory cytokine-mediated cartilage degradation in vitro, respectively. We determined whether knockout of the cellular inhibitor...

Full description

Bibliographic Details
Main Authors: Sophie eGilbert, Lee eMeakin, Cleo Selina Bonnet, Mari eNowell, Warren eLadiges, John eMorton, Victor eDuance, Deborah eMason
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Endocrinology
Subjects:
Osteoarthritis
Bone
articular cartilage
pERK
PKR
P58IPK
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00174/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00174/full

Similar Items