GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells

GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells

Endoplasmic reticulum (ER) membrane contact sites (MCSs) are crucial regulatory hubs in cells, playing roles in signaling, organelle dynamics, and ion and lipid homeostasis. Previous work demonstrated that the highly conserved yeast Ltc/Lam sterol transporters localize and function at ER MCSs. Our a...

Full description

Bibliographic Details
Main Authors: Marina Besprozvannaya, Eamonn Dickson, Hao Li, Kenneth S Ginburg, Donald M Bers, Johan Auwerx, Jodi Nunnari
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-02-01
Series:eLife
Subjects:
membrane contact site
ER-PM contact sites
cortical ER
GRAMD proteins
store operated calcium entry
PIP lipids
Online Access:https://elifesciences.org/articles/31019

Internet

https://elifesciences.org/articles/31019

Similar Items