Diversification of circulating and tumor‐infiltrating plasmacytoid DCs towards the P3 (CD80+ PDL1−)‐pDC subset negatively correlated with clinical outcomes in melanoma patients

Diversification of circulating and tumor‐infiltrating plasmacytoid DCs towards the P3 (CD80+ PDL1−)‐pDC subset negatively correlated with clinical outcomes in melanoma patients

Abstract Objectives Plasmacytoid DCs (pDCs) play a critical yet enigmatic role in antitumor immunity through their pleiotropic immunomodulatory functions. Despite proof of pDC diversity in several physiological or pathological contexts, pDCs have been studied as a whole population so far in cancer....

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Bibliographic Details
Main Authors: Eleonora Sosa Cuevas, Nathalie Bendriss‐Vermare, Stephane Mouret, Florence De Fraipont, Julie Charles, Jenny Valladeau‐Guilemond, Laurence Chaperot, Caroline Aspord
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Clinical & Translational Immunology
Subjects:
clinical outcome
immune subversion
melanoma
pDC subsets
Online Access:https://doi.org/10.1002/cti2.1382

Internet

https://doi.org/10.1002/cti2.1382

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