A Sarcoplasmic Reticulum Localized Protein Phosphatase Regulates Phospholamban Phosphorylation and Promotes Ischemia Reperfusion Injury in the Heart

A Sarcoplasmic Reticulum Localized Protein Phosphatase Regulates Phospholamban Phosphorylation and Promotes Ischemia Reperfusion Injury in the Heart

Summary: Phospholamban (PLN) is a key regulator of sarcolemma calcium uptake in cardiomyocyte; its inhibitory activity to sarcolemma-endoplasmic reticulum calcium ATPase is regulated by phosphorylation. PLN hypophosphorylation is a common molecular feature in the failing heart. The current study pro...

Full description

Bibliographic Details
Main Authors: Toru Akaike, MD, PhD, Na Du, MD, PhD, Gang Lu, PhD, Susumu Minamisawa, MD, PhD, Yibin Wang, PhD, Hongmei Ruan, MD, PhD
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:JACC: Basic to Translational Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X17300505

Internet

http://www.sciencedirect.com/science/article/pii/S2452302X17300505

Similar Items