Incorporation of human iPSC-derived stromal cells creates a pancreatic cancer organoid with heterogeneous cancer-associated fibroblasts

Incorporation of human iPSC-derived stromal cells creates a pancreatic cancer organoid with heterogeneous cancer-associated fibroblasts

Summary: The aggressiveness of pancreatic ductal adenocarcinoma (PDAC) is affected by the tumor microenvironment (TME). In this study, to recapitulate the PDAC TME ex vivo, we cocultured patient-derived PDAC cells with mesenchymal and vascular endothelial cells derived from human induced pluripotent...

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Podrobná bibliografie
Hlavní autoři: Kenta Takeuchi, Shunsuke Tabe, Kenta Takahashi, Kenji Aoshima, Megumi Matsuo, Yasuharu Ueno, Yoichi Furukawa, Kiyoshi Yamaguchi, Masayuki Ohtsuka, Soichiro Morinaga, Yohei Miyagi, Tomoyuki Yamaguchi, Naoki Tanimizu, Hideki Taniguchi
Médium: Článek
Jazyk:English
Vydáno: Elsevier 2023-11-01
Edice:Cell Reports
Témata:
CP: Cancer
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2211124723014328

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http://www.sciencedirect.com/science/article/pii/S2211124723014328

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