satmut_utils: a simulation and variant calling package for multiplexed assays of variant effect

satmut_utils: a simulation and variant calling package for multiplexed assays of variant effect

Abstract The impact of millions of individual genetic variants on molecular phenotypes in coding sequences remains unknown. Multiplexed assays of variant effect (MAVEs) are scalable methods to annotate relevant variants, but existing software lacks standardization, requires cumbersome configuration,...

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Bibliographic Details
Main Authors: Ian Hoskins, Song Sun, Atina Cote, Frederick P. Roth, Can Cenik
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Genome Biology
Subjects:
MAVE
DMS
Mutagenesis
Variant calling
SNP
MNP
Online Access:https://doi.org/10.1186/s13059-023-02922-z

Internet

https://doi.org/10.1186/s13059-023-02922-z

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