Imaging single-channel calcium microdomains by total internal reflection microscopy

The microdomains of Ca2+ in the cytosol around the mouth of open Ca2+ channels are the basic `building blocks' from which cellular Ca2+ signals are constructed. Moreover, the kinetics of local [Ca2+] closely reflect channel gating, so their measurement holds promise as an alternative to electro...

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Bibliographic Details
Main Authors: ANGELO DEMURO, IAN PARKER
Format: Article
Language:English
Published: BMC 2004-01-01
Series:Biological Research
Subjects:
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400025