CHEMICAL STUDY OF Hortia superba (Rutaceae) AND INVESTIGATION OF THE ANTIMYCOBACTERIAL ACTIVITY OF CRUDE EXTRACTS AND CONSTITUENTS ISOLATED FROM Hortia SPECIES
In this paper, the chemical study of Hortia superba and antimycobacterial potential of Hortia species were investigated. Crude extracts and limonoids, alkaloids, dihydrocinnamic acid derivatives and coumarins isolated from Hortia superba, Hortia oreadica and Hortia brasiliana were evaluated against...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2015-01-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422015000100042&lng=en&tlng=en |
| _version_ | 1811233338083508224 |
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| author | Vanessa Gisele Pasqualotto Severino Monteiro Afif Felix Maria Fátima das Graças Fernandes da Silva Rodrigo Lucarini Carlos Henrique Gomes Martins |
| author_facet | Vanessa Gisele Pasqualotto Severino Monteiro Afif Felix Maria Fátima das Graças Fernandes da Silva Rodrigo Lucarini Carlos Henrique Gomes Martins |
| author_sort | Vanessa Gisele Pasqualotto Severino |
| collection | DOAJ |
| description | In this paper, the chemical study of Hortia superba and antimycobacterial potential of Hortia species were investigated. Crude extracts and limonoids, alkaloids, dihydrocinnamic acid derivatives and coumarins isolated from Hortia superba, Hortia oreadica and Hortia brasiliana were evaluated against Mycobacterium tuberculosis H37Rv, Mycobacterium kansasii and Mycobacterium avium. The results obtained demonstrated an inhibitory effect of the dichloromethane extract of leaves of H. oreadica (MIC 31.25 µg mL-1), indolequinazoline (15.62 µg mL-1) and furoquinoline (31.25 µg mL-1) alkaloids, and dihydrocinnamic acid derivatives (62.50 µg mL-1), on the growth of M. tuberculosis. These results are promising in relation to the search for biologically active natural products and could be useful in the development of effective new drugs against mycobacteria. |
| first_indexed | 2024-04-12T11:19:05Z |
| format | Article |
| id | doaj.art-60cffdb58cdf4c3aa5fd3b5593ee4544 |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-04-12T11:19:05Z |
| publishDate | 2015-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-60cffdb58cdf4c3aa5fd3b5593ee45442022-12-22T03:35:26ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642015-01-01381424510.5935/0100-4042.20140290S0100-40422015000100042CHEMICAL STUDY OF Hortia superba (Rutaceae) AND INVESTIGATION OF THE ANTIMYCOBACTERIAL ACTIVITY OF CRUDE EXTRACTS AND CONSTITUENTS ISOLATED FROM Hortia SPECIESVanessa Gisele Pasqualotto SeverinoMonteiro Afif FelixMaria Fátima das Graças Fernandes da SilvaRodrigo LucariniCarlos Henrique Gomes MartinsIn this paper, the chemical study of Hortia superba and antimycobacterial potential of Hortia species were investigated. Crude extracts and limonoids, alkaloids, dihydrocinnamic acid derivatives and coumarins isolated from Hortia superba, Hortia oreadica and Hortia brasiliana were evaluated against Mycobacterium tuberculosis H37Rv, Mycobacterium kansasii and Mycobacterium avium. The results obtained demonstrated an inhibitory effect of the dichloromethane extract of leaves of H. oreadica (MIC 31.25 µg mL-1), indolequinazoline (15.62 µg mL-1) and furoquinoline (31.25 µg mL-1) alkaloids, and dihydrocinnamic acid derivatives (62.50 µg mL-1), on the growth of M. tuberculosis. These results are promising in relation to the search for biologically active natural products and could be useful in the development of effective new drugs against mycobacteria.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422015000100042&lng=en&tlng=enHortia speciesalkaloidsdihydrocinnamic acid derivativesantimycobacterial potential |
| spellingShingle | Vanessa Gisele Pasqualotto Severino Monteiro Afif Felix Maria Fátima das Graças Fernandes da Silva Rodrigo Lucarini Carlos Henrique Gomes Martins CHEMICAL STUDY OF Hortia superba (Rutaceae) AND INVESTIGATION OF THE ANTIMYCOBACTERIAL ACTIVITY OF CRUDE EXTRACTS AND CONSTITUENTS ISOLATED FROM Hortia SPECIES Química Nova Hortia species alkaloids dihydrocinnamic acid derivatives antimycobacterial potential |
| title | CHEMICAL STUDY OF Hortia superba (Rutaceae) AND INVESTIGATION OF THE ANTIMYCOBACTERIAL ACTIVITY OF CRUDE EXTRACTS AND CONSTITUENTS ISOLATED FROM Hortia SPECIES |
| title_full | CHEMICAL STUDY OF Hortia superba (Rutaceae) AND INVESTIGATION OF THE ANTIMYCOBACTERIAL ACTIVITY OF CRUDE EXTRACTS AND CONSTITUENTS ISOLATED FROM Hortia SPECIES |
| title_fullStr | CHEMICAL STUDY OF Hortia superba (Rutaceae) AND INVESTIGATION OF THE ANTIMYCOBACTERIAL ACTIVITY OF CRUDE EXTRACTS AND CONSTITUENTS ISOLATED FROM Hortia SPECIES |
| title_full_unstemmed | CHEMICAL STUDY OF Hortia superba (Rutaceae) AND INVESTIGATION OF THE ANTIMYCOBACTERIAL ACTIVITY OF CRUDE EXTRACTS AND CONSTITUENTS ISOLATED FROM Hortia SPECIES |
| title_short | CHEMICAL STUDY OF Hortia superba (Rutaceae) AND INVESTIGATION OF THE ANTIMYCOBACTERIAL ACTIVITY OF CRUDE EXTRACTS AND CONSTITUENTS ISOLATED FROM Hortia SPECIES |
| title_sort | chemical study of hortia superba rutaceae and investigation of the antimycobacterial activity of crude extracts and constituents isolated from hortia species |
| topic | Hortia species alkaloids dihydrocinnamic acid derivatives antimycobacterial potential |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422015000100042&lng=en&tlng=en |
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