Zidovudine exposure in HIV-1 infected Tanzanian women increases mitochondrial DNA levels in placenta and umbilical cords.

Zidovudine exposure in HIV-1 infected Tanzanian women increases mitochondrial DNA levels in placenta and umbilical cords.

BACKGROUND: Zidovudine (AZT) constitutes part of the recommended regimens for prevention and treatment of HIV-1 infection. At the same time, AZT as well as HIV-1 infection itself may induce mitochondrial damage. In this study, we analyzed the impact of prenatal AZT-exposure on mitochondrial alterati...

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Bibliographic Details
Main Authors: Andrea Kunz, Nicole von Wurmb-Schwark, Julius Sewangi, Judith Ziske, Inga Lau, Paulina Mbezi, Stefanie Theuring, Andrea Hauser, Festo Dugange, Angela Katerna, Gundel Harms
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3407225?pdf=render

Internet

http://europepmc.org/articles/PMC3407225?pdf=render

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