Vascular miR-181b controls tissue factor-dependent thrombogenicity and inflammation in type 2 diabetes

Vascular miR-181b controls tissue factor-dependent thrombogenicity and inflammation in type 2 diabetes

Abstract Background Diabetes mellitus is characterized by chronic vascular inflammation leading to pathological expression of the thrombogenic full length (fl) tissue factor (TF) and its isoform alternatively-spliced (as) TF. Blood-borne TF promotes factor (F) Xa generation resulting in a pro-thromb...

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Bibliographic Details
Main Authors: Marco Witkowski, Mario Witkowski, Mona Saffarzadeh, Julian Friebel, Termeh Tabaraie, Loc Ta Bao, Aritra Chakraborty, Andrea Dörner, Bernd Stratmann, Diethelm Tschoepe, Samantha J. Winter, Andreas Krueger, Wolfram Ruf, Ulf Landmesser, Ursula Rauch
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Cardiovascular Diabetology
Subjects:
Diabetes mellitus
Diabetes complications
Thrombosis
Tissue factor
microRNA
Vascular homeostasis
Online Access:http://link.springer.com/article/10.1186/s12933-020-0993-z

Internet

http://link.springer.com/article/10.1186/s12933-020-0993-z

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