Exosomes derived from human adipose mesenchymal stem cells ameliorate hepatic fibrosis by inhibiting PI3K/Akt/mTOR pathway and remodeling choline metabolism

Exosomes derived from human adipose mesenchymal stem cells ameliorate hepatic fibrosis by inhibiting PI3K/Akt/mTOR pathway and remodeling choline metabolism

Abstract Liver fibrosis is a chronic liver disease with the presence of progressive wound healing response caused by liver injury. Currently, there are no approved therapies for liver fibrosis. Exosomes derived from human adipose mesenchymal stem cells (hADMSCs-Exo) have displayed a prominent therap...

Full description

Bibliographic Details
Main Authors: Zilong Zhang, Jin Shang, Qinyan Yang, Zonglin Dai, Yuxin Liang, Chunyou Lai, Tianhang Feng, Deyuan Zhong, Haibo Zou, Lelin Sun, Yuhao Su, Su Yan, Jie Chen, Yutong Yao, Ying Shi, Xiaolun Huang
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Nanobiotechnology
Subjects:
Liver fibrosis
Human adipose mesenchymal stem cells
Exosomes
Metabolomics
Choline
Online Access:https://doi.org/10.1186/s12951-023-01788-4

Internet

https://doi.org/10.1186/s12951-023-01788-4

Similar Items