Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy

Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy

Recent innovations in nanomaterials inspire abundant novel tumor-targeting CRISPR-based gene therapies. However, the therapeutic efficiency of traditional targeted nanotherapeutic strategies is limited by that the biomarkers vary in a spatiotemporal-dependent manner with tumor progression. Here, we...

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Bibliographic Details
Main Authors: Yongchun Pan, Xiaowei Luan, Fei Zeng, Xuyuan Wang, Shurong Qin, Qianglan Lu, Guanzhong He, Yanfeng Gao, Xiaolian Sun, Xin Han, Bangshun He, Yujun Song
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
CRISPR delivery
Enzyme encapsulation
Logic gate
Hybrid material
Hypoxia
Gene editing
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523003817

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http://www.sciencedirect.com/science/article/pii/S2211383523003817

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