Mitochondrial <i>Glrx2</i> Knockout Augments Acetaminophen-Induced Hepatotoxicity in Mice

Mitochondrial <i>Glrx2</i> Knockout Augments Acetaminophen-Induced Hepatotoxicity in Mice

Acetaminophen (APAP) is one of the most widely used drugs with antipyretic and analgesic effects, and thus hepatotoxicity from the overdose of APAP becomes one of the most common forms of drug-induced liver injury. The reaction towards thiol molecules, such as GSH by APAP metabolite, <i>N</...

Full description

Bibliographic Details
Main Authors: Jing Li, Xuewen Tang, Xing Wen, Xiaoyuan Ren, Huihui Zhang, Yatao Du, Jun Lu
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Antioxidants
Subjects:
glutaredoxin2
acetaminophen
hepatotoxicity
thioredoxin
glutaredoxin system
glutathionylation
Online Access:https://www.mdpi.com/2076-3921/11/9/1643

Internet

https://www.mdpi.com/2076-3921/11/9/1643

Similar Items