ER Stress in ERp57 Knockout Knee Joint Chondrocytes Induces Osteoarthritic Cartilage Degradation and Osteophyte Formation

ER Stress in ERp57 Knockout Knee Joint Chondrocytes Induces Osteoarthritic Cartilage Degradation and Osteophyte Formation

Ageing or obesity are risk factors for protein aggregation in the endoplasmic reticulum (ER) of chondrocytes. This condition is called ER stress and leads to induction of the unfolded protein response (UPR), which, depending on the stress level, restores normal cell function or initiates apoptotic c...

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Bibliographic Details
Main Authors: Yvonne Rellmann, Elco Eidhof, Uwe Hansen, Lutz Fleischhauer, Jonas Vogel, Hauke Clausen-Schaumann, Attila Aszodi, Rita Dreier
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
cartilage
ER stress
osteoarthritis
apoptosis
osteophytes
Online Access:https://www.mdpi.com/1422-0067/23/1/182

Internet

https://www.mdpi.com/1422-0067/23/1/182

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