The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors.

The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors.

Hepatitis C virus (HCV) infects over 170 million people worldwide and is the leading cause of chronic liver diseases, including cirrhosis, liver failure, and liver cancer. Available antiviral therapies cause severe side effects and are effective only for a subset of patients, though treatment outcom...

Full description

Bibliographic Details
Main Authors: Keith P Romano, Akbar Ali, Cihan Aydin, Djade Soumana, Ayşegül Ozen, Laura M Deveau, Casey Silver, Hong Cao, Alicia Newton, Christos J Petropoulos, Wei Huang, Celia A Schiffer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3406087?pdf=render

Internet

http://europepmc.org/articles/PMC3406087?pdf=render

Similar Items