Glutamine metabolic microenvironment drives M2 macrophage polarization to mediate trastuzumab resistance in HER2‐positive gastric cancer

Glutamine metabolic microenvironment drives M2 macrophage polarization to mediate trastuzumab resistance in HER2‐positive gastric cancer

Abstract Background Trastuzumab is a first‐line targeted therapy for human epidermal growth factor receptor‐2 (HER2)‐positive gastric cancer. However, the inevitable occurrence of acquired trastuzumab resistance limits the drug benefit, and there is currently no effective reversal measure. Existing...

Full description

Bibliographic Details
Main Authors: Xingbin Hu, Zhenfeng Ma, Beibei Xu, Shulong Li, Zhiqi Yao, Bishan Liang, Jiao Wang, Wangjun Liao, Li Lin, Chunling Wang, Siting Zheng, Qijing Wu, Qiong Huang, Le Yu, Fenghua Wang, Min Shi
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Cancer Communications
Subjects:
Gastric cancer
glutamine metabolism
macrophage
mathematical model
microvesicles
trastuzumab
Online Access:https://doi.org/10.1002/cac2.12459

Internet

https://doi.org/10.1002/cac2.12459

Similar Items