Vitamin D, Folic Acid and Vitamin B<sub>12</sub> Can Reverse Vitamin D Deficiency-Induced Learning and Memory Impairment by Altering 27-Hydroxycholesterol and S-Adenosylmethionine

Vitamin D, Folic Acid and Vitamin B<sub>12</sub> Can Reverse Vitamin D Deficiency-Induced Learning and Memory Impairment by Altering 27-Hydroxycholesterol and S-Adenosylmethionine

The cholesterol-oxidized metabolite 27-hydroxycholesterol (27-OHC) is synthesized by CYP27A1, which is a key factor in vitamin D and oxysterol metabolism. Both vitamin D and 27-OHC are considered to play important roles in Alzheimer’s disease (AD). The study aims to research the effects of co-supple...

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Bibliographic Details
Main Authors: Lijing Wang, Cui Zhou, Huiyan Yu, Ling Hao, Mengwei Ju, Wenjing Feng, Zhiting Guo, Xuejing Sun, Qiushi Fan, Rong Xiao
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Nutrients
Subjects:
vitamin D
27-hydroxycholesterol
CYP27A1
S-Adenosylmethionine
memory
Alzheimer’s disease
Online Access:https://www.mdpi.com/2072-6643/15/1/132

Internet

https://www.mdpi.com/2072-6643/15/1/132

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