Novel Hydroxypyridine Compound Protects Brain Cells against Ischemic Damage In Vitro and In Vivo

Novel Hydroxypyridine Compound Protects Brain Cells against Ischemic Damage In Vitro and In Vivo

A non-surgical pharmacological approach to control cellular vitality and functionality during ischemic and/or reperfusion-induced phases of strokes remains extremely important. The synthesis of 2-ethyl-6-methyl-3-hydroxypyridinium gammalactone-2,3-dehydro-L-gulonate (3-EA) was performed using a topo...

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Bibliographic Details
Main Authors: Ekaterina Blinova, Egor Turovsky, Elena Eliseikina, Alexandra Igrunkova, Elena Semeleva, Grigorii Golodnev, Rita Termulaeva, Olga Vasilkina, Sofia Skachilova, Yan Mazov, Kirill Zhandarov, Ekaterina Simakina, Konstantin Belanov, Saveliy Zalogin, Dmitrii Blinov
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
experimental brain ischemia
cerebral cortex cell culture
glucose-oxygen deprivation
hydroxypyridine compound
cell death
oxidative stress
Online Access:https://www.mdpi.com/1422-0067/23/21/12953

Internet

https://www.mdpi.com/1422-0067/23/21/12953

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