Coupling of PARP1-mediated chromatin structural changes to transcriptional RNA polymerase II elongation and cotranscriptional splicing

Coupling of PARP1-mediated chromatin structural changes to transcriptional RNA polymerase II elongation and cotranscriptional splicing

Abstract Background Recently, we showed that PARP1 is involved in cotranscriptional splicing, possibly by bridging chromatin to RNA and recruiting splicing factors. It also can influence alternative splicing decisions through the regulation of RNAPII elongation. In this study, we investigated the ef...

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Bibliographic Details
Main Authors: Elena A. Matveeva, Qamar M. H. Al-Tinawi, Eric C. Rouchka, Yvonne N. Fondufe-Mittendorf
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Epigenetics & Chromatin
Subjects:
Splicing
RNA polymerase II
Epigenetics
Poly(ADP)ribose polymerase
Polymerase elongation
Nucleosomes
Online Access:http://link.springer.com/article/10.1186/s13072-019-0261-1

Internet

http://link.springer.com/article/10.1186/s13072-019-0261-1

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