Optimized conditions for gene transduction into primary immune cells using viral vectors

Abstract Chimeric antigen receptor (CAR) T cell therapy has emerged as a promising modality for anti-cancer treatment. Its efficacy is quite remarkable in hematological tumors. Owing to their excellent clinical results, gene- modified cell therapies, including T cells, natural killer (NK) cells, and...

Full description

Bibliographic Details
Main Authors: Yeongrin Kim, Da Yeon Lee, Ji U Choi, Jin Song Park, So Myoung Lee, Chung Hyo Kang, Chi Hoon Park
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-39597-2