The antidepressant effects of GM-CSF are mediated by the reduction of TLR4/NF-ĸB-induced IDO expression

The antidepressant effects of GM-CSF are mediated by the reduction of TLR4/NF-ĸB-induced IDO expression

Abstract Background Indoleamine 2, 3-dioxygenase 1 (IDO) is responsible for the progression of the kynurenine pathway. This pathway has been implicated in the pathophysiology of inflammation-induced depression in which conventional antidepressants are not effective. It has been reported that granulo...

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Bibliographic Details
Main Authors: Sara Hemmati, Mohammad Amin Sadeghi, Razieh Mohammad Jafari, Hasan Yousefi-Manesh, Ahmad Reza Dehpour
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Neuroinflammation
Subjects:
Depression
Lipopolysaccharide
Granulocyte-macrophage stimulating factor
Indoleamine 2, 3-dioxygenase
NF-ĸB
Inflammation-induced depression
Online Access:http://link.springer.com/article/10.1186/s12974-019-1509-1

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http://link.springer.com/article/10.1186/s12974-019-1509-1

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