Vinpocetine, a Phosphodiesterase Type 1 Inhibitor, Mitigates Locomotor Hyperactivity in Female Mice Exposed to Lead During Development
Background/Objectives Studies in rodents indicate that disruptions in both cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) signaling pathways are involved in the development of hyperactive behavior. We examined whether vinpocetine, a phosphodiesterase type 1 inhibitor...
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2025-02-01
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| author | Ulisses C. Araujo Fernanda Nunes Bruno S. Gonçalves Regina A. A. Gomes Maria de Fátima R. Moreira Andre Nunes-Freitas Thomas E. Krahe Yael de Abreu-Villaça Alex C. Manhães Cláudio C. Filgueiras |
| author_facet | Ulisses C. Araujo Fernanda Nunes Bruno S. Gonçalves Regina A. A. Gomes Maria de Fátima R. Moreira Andre Nunes-Freitas Thomas E. Krahe Yael de Abreu-Villaça Alex C. Manhães Cláudio C. Filgueiras |
| author_sort | Ulisses C. Araujo |
| collection | DOAJ |
| description | Background/Objectives Studies in rodents indicate that disruptions in both cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) signaling pathways are involved in the development of hyperactive behavior. We examined whether vinpocetine, a phosphodiesterase type 1 inhibitor that enhances brain cAMP and cGMP levels, could mitigate locomotor hyperactivity in mice exposed to lead during early development. Methods Swiss mice were exposed to 90 ppm of lead in their drinking water throughout gestation and the first ten postnatal days. At postnatal day 10 (PN10), blood lead levels (BLLs) were about 30 µg/dL. At PN30, animals either received vinpocetine (20 mg/kg, i.p.) or a vehicle 4 h before the evaluation of locomotor activity in the open field. Results Lead-exposed males did not display differences in locomotor activity compared to controls, while lead-exposed females showed a significant increase in locomotion. Vinpocetine treatment significantly reversed the lead-induced hyperactivity in females. Conclusions These findings suggest that the cAMP and cGMP signaling pathways play a role in the hyperactivity induced by lead exposure. |
| first_indexed | 2025-03-14T15:13:38Z |
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| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2025-03-14T15:13:38Z |
| publishDate | 2025-02-01 |
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| series | Brain Sciences |
| spelling | doaj.art-60f65a2119ef4822bf7adb868b689d072025-02-25T13:16:46ZengMDPI AGBrain Sciences2076-34252025-02-0115215010.3390/brainsci15020150Vinpocetine, a Phosphodiesterase Type 1 Inhibitor, Mitigates Locomotor Hyperactivity in Female Mice Exposed to Lead During DevelopmentUlisses C. Araujo0Fernanda Nunes1Bruno S. Gonçalves2Regina A. A. Gomes3Maria de Fátima R. Moreira4Andre Nunes-Freitas5Thomas E. Krahe6Yael de Abreu-Villaça7Alex C. Manhães8Cláudio C. Filgueiras9Departamento de Ciências Fisiológicas, Universidade do Estado do Rio de Janeiro, Av. Prof. Manoel de Abreu 444, 5 andar, Vila Isabel, Rio de Janeiro 20550-170, RJ, BrazilDepartamento de Ciências Fisiológicas, Universidade do Estado do Rio de Janeiro, Av. Prof. Manoel de Abreu 444, 5 andar, Vila Isabel, Rio de Janeiro 20550-170, RJ, BrazilDepartamento de Ciências Fisiológicas, Universidade do Estado do Rio de Janeiro, Av. Prof. Manoel de Abreu 444, 5 andar, Vila Isabel, Rio de Janeiro 20550-170, RJ, BrazilCentro de Estudos da Saúde do Trabalhador e Ecologia Humana (CESTEH), Escola Nacional de Saúde Pública, Rua Leopoldo Bulhões 1480, Manguinhos, Rio de Janeiro 21040-210, RJ, BrazilCentro de Estudos da Saúde do Trabalhador e Ecologia Humana (CESTEH), Escola Nacional de Saúde Pública, Rua Leopoldo Bulhões 1480, Manguinhos, Rio de Janeiro 21040-210, RJ, BrazilDepartamento de Ciências Fisiológicas, Universidade do Estado do Rio de Janeiro, Av. Prof. Manoel de Abreu 444, 5 andar, Vila Isabel, Rio de Janeiro 20550-170, RJ, BrazilDepartamento de Psicologia, Pontifícia Universidade Católica do Rio de Janeiro, Rio de Janeiro 22451-000, RJ, BrazilDepartamento de Ciências Fisiológicas, Universidade do Estado do Rio de Janeiro, Av. Prof. Manoel de Abreu 444, 5 andar, Vila Isabel, Rio de Janeiro 20550-170, RJ, BrazilDepartamento de Ciências Fisiológicas, Universidade do Estado do Rio de Janeiro, Av. Prof. Manoel de Abreu 444, 5 andar, Vila Isabel, Rio de Janeiro 20550-170, RJ, BrazilDepartamento de Ciências Fisiológicas, Universidade do Estado do Rio de Janeiro, Av. Prof. Manoel de Abreu 444, 5 andar, Vila Isabel, Rio de Janeiro 20550-170, RJ, BrazilBackground/Objectives Studies in rodents indicate that disruptions in both cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) signaling pathways are involved in the development of hyperactive behavior. We examined whether vinpocetine, a phosphodiesterase type 1 inhibitor that enhances brain cAMP and cGMP levels, could mitigate locomotor hyperactivity in mice exposed to lead during early development. Methods Swiss mice were exposed to 90 ppm of lead in their drinking water throughout gestation and the first ten postnatal days. At postnatal day 10 (PN10), blood lead levels (BLLs) were about 30 µg/dL. At PN30, animals either received vinpocetine (20 mg/kg, i.p.) or a vehicle 4 h before the evaluation of locomotor activity in the open field. Results Lead-exposed males did not display differences in locomotor activity compared to controls, while lead-exposed females showed a significant increase in locomotion. Vinpocetine treatment significantly reversed the lead-induced hyperactivity in females. Conclusions These findings suggest that the cAMP and cGMP signaling pathways play a role in the hyperactivity induced by lead exposure.https://www.mdpi.com/2076-3425/15/2/150locomotor hyperactivityheavy metalcyclic nucleotidestype 1 phosphodiesterase |
| spellingShingle | Ulisses C. Araujo Fernanda Nunes Bruno S. Gonçalves Regina A. A. Gomes Maria de Fátima R. Moreira Andre Nunes-Freitas Thomas E. Krahe Yael de Abreu-Villaça Alex C. Manhães Cláudio C. Filgueiras Vinpocetine, a Phosphodiesterase Type 1 Inhibitor, Mitigates Locomotor Hyperactivity in Female Mice Exposed to Lead During Development Brain Sciences locomotor hyperactivity heavy metal cyclic nucleotides type 1 phosphodiesterase |
| title | Vinpocetine, a Phosphodiesterase Type 1 Inhibitor, Mitigates Locomotor Hyperactivity in Female Mice Exposed to Lead During Development |
| title_full | Vinpocetine, a Phosphodiesterase Type 1 Inhibitor, Mitigates Locomotor Hyperactivity in Female Mice Exposed to Lead During Development |
| title_fullStr | Vinpocetine, a Phosphodiesterase Type 1 Inhibitor, Mitigates Locomotor Hyperactivity in Female Mice Exposed to Lead During Development |
| title_full_unstemmed | Vinpocetine, a Phosphodiesterase Type 1 Inhibitor, Mitigates Locomotor Hyperactivity in Female Mice Exposed to Lead During Development |
| title_short | Vinpocetine, a Phosphodiesterase Type 1 Inhibitor, Mitigates Locomotor Hyperactivity in Female Mice Exposed to Lead During Development |
| title_sort | vinpocetine a phosphodiesterase type 1 inhibitor mitigates locomotor hyperactivity in female mice exposed to lead during development |
| topic | locomotor hyperactivity heavy metal cyclic nucleotides type 1 phosphodiesterase |
| url | https://www.mdpi.com/2076-3425/15/2/150 |
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