Circular breakdown of neural networks due to loss of deubiquitinating enzyme (UCH-L1) in gracile axonal dystrophy (gad) mouse

Circular breakdown of neural networks due to loss of deubiquitinating enzyme (UCH-L1) in gracile axonal dystrophy (gad) mouse

Gracile axonal dystrophy (gad) mouse shows tremor, ataxia and muscular atrophy of hind limbs from about 80-days of age. These clinical features become progressively severe to death. Pathological examination reveals that main and early axonal degeneration exists in a long ascending nervous tract in d...

Full description

Bibliographic Details
Main Author: Tateki Kikuchi
Format: Article
Language:English
Published: AIMS Press 2021-12-01
Series:AIMS Molecular Science
Subjects:
gracile axonal dystrophy (gad) mouse
deubiquitinating enzyme (uch-l1)
axonal spheroids
reactive astrocytes
amyloid precursor protein
amyloid β-protein
substance p
ubiquitin
Online Access:https://www.aimspress.com/article/doi/10.3934/molsci.2021024?viewType=HTML

Internet

https://www.aimspress.com/article/doi/10.3934/molsci.2021024?viewType=HTML

Similar Items