Pentose Pathway Activation Is Superior to Increased Glycolysis for Therapeutic Angiogenesis in Peripheral Arterial Disease

Pentose Pathway Activation Is Superior to Increased Glycolysis for Therapeutic Angiogenesis in Peripheral Arterial Disease

Background In endothelial cells (ECs), glycolysis, regulated by PFKFB3 (6‐phosphofructo‐2‐kinase/fructose‐2,6‐biphosphatase, isoform‐3), is the major metabolic pathway for ATP generation. In preclinical peripheral artery disease models, VEGF165a (vascular endothelial growth factor165a) and microRNA‐...

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Bibliographic Details
Main Authors: Abdelrahman A. Zaied, Masuko Ushio‐Fukai, Tohru Fukai, Anita Kovacs‐Kasa, Suhib Alhusban, Varadarajan Sudhahar, Vijay C. Ganta, Brian H. Annex
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
endothelial metabolism
glycolysis
hypoxia dependent angiogenesis
microRNA‐93
pentose phosphate pathway
vascular permeability
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.122.027986

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https://www.ahajournals.org/doi/10.1161/JAHA.122.027986

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