Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis

Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis

Summary: Kynurenine monooxygenase (KMO) blockade protects against multiple organ failure caused by acute pancreatitis (AP), but the link between KMO and systemic inflammation has eluded discovery until now. Here, we show that the KMO product 3-hydroxykynurenine primes innate immune signaling to exac...

Full description

Bibliographic Details
Main Authors: Alastair J. Hayes, Xiaozhong Zheng, James O’Kelly, Lucile P.A. Neyton, Natalia A. Bochkina, Iain Uings, John Liddle, J. Kenneth Baillie, George Just, Margaret Binnie, Natalie Z.M. Homer, Toby B.J. Murray, James Baily, Kris McGuire, Christos Skouras, O. James Garden, Scott P. Webster, John P. Iredale, Sarah E.M. Howie, Damian J. Mole
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Cell Reports
Subjects:
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472300774X

Internet

http://www.sciencedirect.com/science/article/pii/S221112472300774X

Similar Items