ASCL1, NKX2-1, and PROX1 co-regulate subtype-specific genes in small-cell lung cancer

ASCL1, NKX2-1, and PROX1 co-regulate subtype-specific genes in small-cell lung cancer

Summary: Lineage-defining transcription factors (LTFs) play key roles in small-cell lung cancer (SCLC) pathophysiology. Delineating the LTF-regulated genes operative in SCLC could provide a road map to identify SCLC dependencies. We integrated chromatin landscape and transcriptome analyses of patien...

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Bibliographic Details
Main Authors: Karine Pozo, Rahul K. Kollipara, Demetra P. Kelenis, Kathia E. Rodarte, Morgan S. Ullrich, Xiaoyang Zhang, John D. Minna, Jane E. Johnson
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:iScience
Subjects:
molecular biology
bioinformatics
cancer systems biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221009214

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http://www.sciencedirect.com/science/article/pii/S2589004221009214

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