Uptake of Aβ by OATPs might be a new pathophysiological mechanism of Alzheimer disease

Abstract Background The accumulation of neurotoxic amyloid-beta (Aβ) in the brain is a characteristic of Alzheimer's disease (AD), at the same time, it is possible alterations of liver function could affect brain Aβ levels through changes in blood Aβ concentration. Over the last decade, a numbe...

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Bibliographic Details
Main Authors: Jinhua Wen, Menghua Zhao, Wenxiong Sun, Xiaohua Cheng, Luyi Yu, Duanwen Cao, Pu Li
Format: Article
Language:English
Published: BMC 2021-09-01
Series:BMC Neuroscience
Subjects:
Online Access:https://doi.org/10.1186/s12868-021-00658-9