Raloxifene retards the progression of adjacent segmental intervertebral disc degeneration by inhibiting apoptosis of nucleus pulposus in ovariectomized rats

Raloxifene retards the progression of adjacent segmental intervertebral disc degeneration by inhibiting apoptosis of nucleus pulposus in ovariectomized rats

Abstract Background Adjacent segmental intervertebral disk degeneration (ASDD) is a major complication secondary to lumbar fusion. Although ASSD pathogenesis remains unclear, the primary cause of intervertebral disk degeneration (IVDD) development is apoptosis of nucleus pulposus (NP). Raloxifene (R...

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Bibliographic Details
Main Authors: Qi Sun, Xin-Yu Nan, Fa-Ming Tian, Fang Liu, Shao-Hua Ping, Zhuang Zhou, Liu Zhang
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Osteoporosis
Animal
Apoptosis
Intervertebral disk
Fusion
Online Access:https://doi.org/10.1186/s13018-021-02504-4

Internet

https://doi.org/10.1186/s13018-021-02504-4

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