The Protective Effect of Pilose Antler Peptide on CUMS-Induced Depression Through AMPK/Sirt1/NF-κB/NLRP3-Mediated Pyroptosis

The Protective Effect of Pilose Antler Peptide on CUMS-Induced Depression Through AMPK/Sirt1/NF-κB/NLRP3-Mediated Pyroptosis

Background: Pilose antler peptide (PAP), prepared from the pilose antler of Cervus nippon Temminck, is widely used in traditional Chinese medicine (TCM) against various inflammatory disorders. TCM prescriptions containing pilose antler are often prescribed clinically to treat depression. However, th...

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Bibliographic Details
Main Authors: Yue Hu, Min Zhao, Tong Zhao, Mingming Qi, Guangda Yao, Yu Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
pilose antler peptide
CUMS
AMPK
SIRT1
NF-κB
NLRP3
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.815413/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.815413/full

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