Kisspeptin regulates the proliferation and apoptosis of ovary granulosa cells in polycystic ovary syndrome by modulating the PI3K/AKT/ERK signalling pathway

Kisspeptin regulates the proliferation and apoptosis of ovary granulosa cells in polycystic ovary syndrome by modulating the PI3K/AKT/ERK signalling pathway

Highlights 1. Kisspeptin expression is decreased in ovaries of PCOS rat 2. Kisspeptin promotes proliferation and inhibits apoptosis of granulosa cells 3. Kisspeptin alleviates oxidative stress of granulosa cells 4. Kisspeptin activates PI3K/AKT/ERK signalling pathway

Bibliographic Details
Main Authors: Pingping Sun, Yuemin Zhang, Lilan Sun, Na Sun, Jinguang Wang, Huagang Ma
Format: Article
Language:English
Published: BMC 2023-01-01
Series:BMC Women's Health
Subjects:
Kisspeptin
Polycystic ovary syndrome
Granulosa cell
Oxidative stress
Apoptosis
PI3K/AKT/ERK signalling
Online Access:https://doi.org/10.1186/s12905-022-02154-6

Internet

https://doi.org/10.1186/s12905-022-02154-6

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