Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis

Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis

Linezolid is an efficacious medication for the treatment of drug-resistant tuberculosis but has been associated with serious safety issues that can result in treatment interruption. The objectives of this study were thus to build a population pharmacokinetic model and to use the developed model to e...

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Bibliographic Details
Main Authors: Laurynas Mockeliunas, Lina Keutzer, Marieke G. G. Sturkenboom, Mathieu S. Bolhuis, Lotte M. G. Hulskotte, Onno W. Akkerman, Ulrika S. H. Simonsson
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Pharmaceutics
Subjects:
tuberculosis
population pharmacokinetics
linezolid
auto-inhibition of linezolid elimination
model-informed precision dosing
simulation
Online Access:https://www.mdpi.com/1999-4923/14/4/753

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https://www.mdpi.com/1999-4923/14/4/753

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