MACF1 overexpression in BMSCs alleviates senile osteoporosis in mice through TCF4/miR-335–5p signaling pathway

MACF1 overexpression in BMSCs alleviates senile osteoporosis in mice through TCF4/miR-335–5p signaling pathway

Background: The decreased osteogenic differentiation ability of mesenchymal stem cells (MSCs) is one of the important reasons for SOP. Inhibition of Wnt signaling in MSCs is closely related to SOP. Microtubule actin crosslinking factor 1 (MACF1) is an important regulator in Wnt/β-catenin signal tran...

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Bibliographic Details
Main Authors: Kewen Zhang, Wuxia Qiu, Hui Li, Jun Li, Pai Wang, Zhihao Chen, Xiao Lin, Airong Qian
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Journal of Orthopaedic Translation
Subjects:
MACF1
Senile osteoporosis
Bone formation
miR-335-5p
Wnt signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X2300013X

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http://www.sciencedirect.com/science/article/pii/S2214031X2300013X

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