Pien-Tze-Huang alleviates CCl4-induced liver fibrosis through the inhibition of HSC autophagy and the TGF-β1/Smad2 pathway

Pien-Tze-Huang alleviates CCl4-induced liver fibrosis through the inhibition of HSC autophagy and the TGF-β1/Smad2 pathway

Ethnopharmacological relevance: Pien-Tze-Huang (PZH)—a traditional Chinese medicine (TCM) compound—has been employed to treat various liver inflammation and tumors for over 10 decades. Interestingly, most of the pharmacological effects had been validated and explored toward liver ailment along with...

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Bibliographic Details
Main Authors: Yuqin Zhang, Liping Hua, Chunfeng Lin, Mingzhou Yuan, Wei Xu, Anand Raj D., Baskar Venkidasamy, Carlos L. Cespedes-Acuna, Shivraj Hariram Nile, Guohong Yan, Haiyin Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
Pien-Tze-Huang
liver fibrosis
hepatic stellate cell
autophagy
transforming growth factor-β1
matrix metalloproteinase
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.937484/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.937484/full

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